Effects of Rosuvastain on Bone Healing

Effects of Rosuvastain on Bone Healing

Statin has been used in other indication for their principle discovery due to their pleotropic effects. In the present study we would like to test the hypothesis of healing effects of rosuvastatin on induced bone lesion model in a rabbits. To do so, a bone injury rabbit model were used and the rabbi...

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Veröffentlicht in:Research journal of pharmacy and technology 2023-06, Vol.16 (6), p.2705-2708
Hauptverfasser: H. Saeed, Hiba, Al-Saffar, Maha T., S. Mahmood, Abdulsattar
Format: Artikel
Sprache:eng
Schlagworte:
Angiogenesis
Bones
Conflicts of interest
Experiments
Fractures
Histology
Inflammation
Intervention
Lipids
Metabolism
Rabbits
Statins
Vascular endothelial growth factor
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Zusammenfassung:Statin has been used in other indication for their principle discovery due to their pleotropic effects. In the present study we would like to test the hypothesis of healing effects of rosuvastatin on induced bone lesion model in a rabbits. To do so, a bone injury rabbit model were used and the rabbit was administered rosuvastatin daily and sacrificed continuously for histopathology at day 7, day 14, and day 21. Results indicated that rosuvastatin induced beneficial healing process on the bone injury. Conclusion: bone healing could be a target for healing using rosuvastatin.
ISSN:0974-3618
0974-360X
0974-306X
DOI:10.52711/0974-360X.2023.00444