Synthesis, Characterization and In vitro Antimicrobial Assessments of a New Series Benzoimidazoles Incorporated Quinazoline and Thiazine Analogues

In this study, several aromatic groups were inserted to synthesize various4-oxo-1,4-dihydroquinazolin [4a-f] and 4-oxo-2H-benzo[1,3]thiazin[5a-f] linked to benzoimidazole rings. The chemical structures of the synthesized benzoimidazole derivatives were corroborated by physicochemical properties, ele...

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Veröffentlicht in:Research journal of pharmacy and technology 2023-08, Vol.16 (8), p.3852-3858
1. Verfasser: Kareem Khan, Ayad
Format: Artikel
Sprache:eng
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Zusammenfassung:In this study, several aromatic groups were inserted to synthesize various4-oxo-1,4-dihydroquinazolin [4a-f] and 4-oxo-2H-benzo[1,3]thiazin[5a-f] linked to benzoimidazole rings. The chemical structures of the synthesized benzoimidazole derivatives were corroborated by physicochemical properties, elemental micro analysis (C,H,N) and some spectroscopic techniques such as (FTIR, 1H-NMR, 13C-NMR). In vitro antimicrobial assessmentfor newly synthesized target compounds against six types of pathogenic bacteria and one type of fungi was investigated which is comparable to azithromycin (as antibacterial), Itraconazole (antifungal) reference drugs.The results obtained showed that most of the compounds have a potential good to medium activity against these different types of microorganisms.
ISSN:0974-3618
0974-360X
0974-306X
DOI:10.52711/0974-360X.2023.00636