Electrochemical Selective Mono‐ and Polychlorination of Substituted Thiophenes

An environmentally friendly and efficient electrochemical chlorination of thiophenes has been developed. The monochlorination, dichlorination and trichlorination of thiophenes are selectively achieved. Notably, the reaction has the merits of mild conditions, excellent functional group tolerance, high yields and selectivity, and the capacity for scale‐up, thus providing a synthetically useful alternative to access mono‐ and polychlorinated thiophenes. A green and efficient electrochemical method for the selective monochlorination, dichlorination, and trichlorination of 2‐substituted thiophenes has been developed.