Catalytic amination of polychloroarenes promoted by the Buchwald ligands

Catalytic amination of polychloroarenes promoted by the Buchwald ligands

Palladium-catalyzed amination of 1,2,4,5-tetrachlorobenzene with morpholine or pyrrolidine in the presence of 2-dicyclohexylphosphino-2’-(dimethylamino)biphenyl (DavePhos, the Buchwald ligand) afforded the corresponding 2,4,5-trichloroaniline derivatives in moderate yields. In the cases of hexachlor...

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Veröffentlicht in:Russian chemical bulletin 2023-11, Vol.72 (11), p.2749-2753
Hauptverfasser: Vasil’ev, A. A., Burukin, A. A., Zhdankina, G. M., Zlotin, S. G.
Format: Artikel
Sprache:eng
Schlagworte:
Brief Communications
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Hexachlorobenzene
Hydrodechlorination
Inorganic Chemistry
Ligands
Organic Chemistry
Palladium
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Beschreibung
Zusammenfassung:Palladium-catalyzed amination of 1,2,4,5-tetrachlorobenzene with morpholine or pyrrolidine in the presence of 2-dicyclohexylphosphino-2’-(dimethylamino)biphenyl (DavePhos, the Buchwald ligand) afforded the corresponding 2,4,5-trichloroaniline derivatives in moderate yields. In the cases of hexachlorobenzene as well as other Buchwald ligands, the amination products were formed in low yields and the process was accompanied by hydrodechlorination.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-023-4081-x