Radiopharmaceuticals Based on Ligands to Gastrin-Releasing Peptide Receptors: Current State of the Issue and Russian Developments

Data are presented on ligands based on bombesin derivatives, which are peptides that specifically bind to gastrin-releasing factor receptors, that are promising for use in nuclear medicine. An analysis of developments related to the creation of radiopharmaceuticals (RPs) based on gastrin-releasing p...

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Veröffentlicht in:	Nanobiotechnology Reports (Online) 2023-08, Vol.18 (4), p.643-649
Hauptverfasser:	Maystrenko, D. N., Stanzhevsky, A. A., Sergunova, K. A., Shatik, S. V., Antuganov, D. O., Sysoev, D. S., Nadporozhsky, M. S., Konevega, A. L., Trashkov, A. P., Molchanov, O. E., Maksimov, V. I., Chipiga, L. A., Vodovatov, A. V., Popova, A. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry and Materials Science Industrial and Production Engineering Ligands Machines Manufacturing Materials Science Nanobiomedicine and Nanopharmaceutics Nanotechnology Nuclear medicine Peptides Processes Radiation therapy Radioisotopes Receptors Releasing
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Zusammenfassung:	Data are presented on ligands based on bombesin derivatives, which are peptides that specifically bind to gastrin-releasing factor receptors, that are promising for use in nuclear medicine. An analysis of developments related to the creation of radiopharmaceuticals (RPs) based on gastrin-releasing peptide-receptor agonists for radionuclide diagnostics and systemic radiation therapy is carried out. The stages of pharmaceutical development of the first Russian RPs 68 Ga-NOTA-AMBA and 177 Lu-DOTA-AMBA are described, including the synthesis technology using automated modules, as well as drug specifications.
ISSN:	2635-1676 1995-0780 2635-1684 1995-0799
DOI:	10.1134/S2635167623600177