Unveiling the Influence of Tumor Microenvironment and Spatial Heterogeneity on Temozolomide Resistance in Glioblastoma Using an Advanced Human In Vitro Model of the Blood‐Brain Barrier and Glioblastoma (Small 52/2023)

Microfluidic Models In article number 2302280, Andrea Pavesi and co‐workers develop an in vitro 3D glioblastoma model, that incorporates a perfusable blood‐brain barrier. The model recapitulates key features of clinical disease, such as a diffusive infiltrating tumor front and tumor‐associated dysregulation of vascular permeability. The authors further demonstrate the compatibility with next‐generation ultra‐sensitive mass spectrometry to explore proteins involved in tumorigenesis and drug resistance.