The oxidative damage induced by lead sulfide nanoparticles in rat kidney

Backgrounds Lead sulfide nanoparticles (PbS NPs) are an important semiconductor material, which has been widely used in light-emitting diodes (LEDs), biological fluorescent probes, biological in vivo imaging, infrared detection, solar receivers and other fields, and they are used in the field of biomedicine. Live tissue imaging has shown great application prospects, which will increase the chance of human exposure in the future, which has greatly attracted people's attention to its safety evaluation. Objectives To clarify the toxic mechanism of lead sulfide nanoparticles on the kidney, and provide a basis for finding effective intervention measures. Results The results showed that the activity of SOD, GSH-Px and CAT in the kidney tissue of rats in the lead sulfide nanoparticles-exposed group was significantly lower than that of the control group ( P