Visible-Light-Driven α-C(sp3)–H Bond Functionalization of Glycine Derivatives

The glycine motif is widely prevalent in bioactive peptides. Thus, the direct and precise modification of glycine derivatives has attracted significant attention over the past few decades. Among various protocols for the modification of glycine derivatives, the visible-light-driven direct α-C(sp3)–H...

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Veröffentlicht in:Catalysts 2023-12, Vol.13 (12), p.1502
Hauptverfasser: Tian, Yao, Bu, Xiubin, Chen, Yuanrui, Wang, Luohe, E, Junnan, Zeng, Jing, Xu, Hao, Han, Aihong, Yang, Xiaobo, Zhao, Zhen
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Sprache:eng
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Zusammenfassung:The glycine motif is widely prevalent in bioactive peptides. Thus, the direct and precise modification of glycine derivatives has attracted significant attention over the past few decades. Among various protocols for the modification of glycine derivatives, the visible-light-driven direct α-C(sp3)–H bond functionalization of glycine derivatives has emerged as a powerful tool to achieve this objective, owing to its merits in atom economy, selectivity, reaction simplicity, and sustainability. This review summarizes the recent advancements in visible-light-driven direct α-C(sp3)–H bond functionalization of glycine derivatives. The contents of this review are organized based on the photocatalysts employed and the various reaction modes in the functionalization process. The mechanism, the challenges encountered, and future trends are also discussed, enabling readers to understand the current developmental status in this field.
ISSN:2073-4344
2073-4344
DOI:10.3390/catal13121502