FORMULATION AND EVALUATION OF BILAYER FLOATING TABLETS FOR THE TREATMENT OF DIABETES MELLITUS

Diabetes is a chronic disorder. It may be characterized by hyperglycaemia. These may help ininsulin secretion defects and both insulin action. Due to development of insulin resistance theinadequate insulin secretion and tissues dimension may lead to abnormalities of fats,carbohydrate and metabolism of protein. These may lead to change or may increases theconcentration of blood glucose level. In the current research, Repaglinide and Glipizide are used which are anti-diabetic drug used to treat type 2 DM and belongs to the class of meglitinides. Hydroxypropylmethyl cellulose, Sodium carboxymethyl cellulose, Microcrystalline cellulose, Sodium starch glycolate, Sodium bicarbonate, Citric acid, Magnesium stearate, Sodium lauryl sulphate are used as excipients. For the conformity of the drug, UV spectroscopy was performed. Repaglidine showed the absorbance at 241nm and Glipizide showed the absorbance at 276nm. Due to dispersion of potassium bromide the IR spectrum of drug was measured in solid state. The peak of repaglinide was confirmed by DSC study. The peak temperature is at 132.90C. From the graph it was confirmed that the melting point of repaglidine is at 1310C -1340C and for glipizide is at 2100C -2140C. The peak of glipizide was confirmed by DSC study and the peak temperature is at 214.160C. The drug and excipients interaction are done by FTIR study. This study shows that there is no interaction with functional groups. From the result of in-vitro study it was show that F1 release 99.63% of drug release within a 1hr. Thickness and drug content was in the range of 96-99%. Floating lag time was observed less than 40 sec for all batches. Total floating time was observed more than 12 hrs. For immediate release layer, thickness and drug content are in the range of 90-99% and for sustained release layer 95-99%. The weight variation and friability test were found within the range. The buoyancy of bilayer floating tablet was studied at 37 ± 0.50C in 200 ml of 1.2 pHbuffer. The floating time of bilayer layer tablet is more than 12hrs. In stability study, for the determination of different parameters sample is withdrawn periodically and analyzed.