Divalproex Sodium Niosomes: Formulation and Evaluation for the Treatment of Epilepsy

Epilepsy and other seizure disorders may be managed and treated with the use of a medicine known as divalproex sodium, which is a kind of anti-epileptic medication. The study was carried out with the consideration of these three goals in mind. The completion of this research effort resulted in the loading of an anti-epileptic medication into niosomes for the treatment ofepilepsy. These niosomes are able to provide the patient control over the dose that they get. The formulations of niosomes were made better by modifying the area of Tween and Span in the amounts that they occupy, respectively. In order to prepare the formulations, the film hydration method was carried out. After that, the formulation was examined so that its viscosity, morphological properties, and encapsulation efficiency could be figured out. It was found that niosomes made with Tween 80 and Span 60 were capable of entrapping considerable amounts of the drug that they were designed to target. After that, the niosomes were produced by utilising a number of different concentrations. After that, they were optimised at effective concentrations, evaluated for gelation temperature, melting temperature, and heat of enthalpies,and exhibited findings that were to the satisfaction of the researcher. The formulations of the niosomes were tested in vitro, and the results showed that they delivered an appropriate level of medicine delivery. As a consequence of this, we are in a position to arrive at the conclusionthat the niosomes have the potential to be a successful technique for the creation of an anti- epileptic medication