Anti Inflammatory Effects of Indonesian Kecombrang Fruit (Etlingera Elatior) in The Treatment of Sepsis

Sepsis is a potentially fatal organ dysfunction caused by disruption of the host's response to infection facilitated by inflammation and endothelial stress. In this situation, it is believed that Kecombrang (Etlingera elatior) can suppress inflammation and oxidative stress through the control of NF-kB. Therefore, this study investigates the anti-inflammatory effect of fruit extracts ofKecombrang in the Mus musculus sepsis model. The analysis was conducted using 20 Mus musculus, equally divided into four groups, where the control received lipopolysaccharide (LPS) induction. MP1 group was pretreated with methanol extracts of Kecombrang fruit (4.2 mg/20 gr) for five days before induction of LPS. Meanwhile, MP2 was treated with methanol extracts of Kecombrang fruit (4.2 mg/20 gr) for five days after induction of LPS. MP3 group was simultaneously treated with LPS induction and methanol extracts of Kecombrang fruit (4.2 mg/20 gr). The measured outcome was the serum concentration of NFkB and Caspase 3, and the data were analyzed using ANOVA with p