ANTI-THROMBOTIC AND ANTI-PLATELET ACTIVITY OF SOME ANTI-OXIDANTS

Thrombosis is the formation of a blood clot, called a thrombus, inside blood vessel. Thrombosis is a complicated interaction of platelets and plasma proteins.Platelets play important roles in the pathogenesis of thrombosis. These include their adherence to the sites of vessel injury, aggregation to form hemostatic plugs or thrombi, and acceleration of the coagulation cascades leading to the formation of thrombosis. The prevention of arterial thrombotic diseases has a high priority in developed countries. An unhealthy eating habits could be a major risk factor for thrombotic event. Unhealthy eating habits could be a major risk factor for thrombotic events.Daily use of an anti?thrombotic diet may be a simple and efficient method of prevention. Deep vein thrombosis (DVT) and pulmonary embolism (PE), two types of venous thrombosis, affect about 1 in 1000 adults each year.The primary objectiveofthepresentstudywastofindanti-thrombotic and anti-platelet activities of some anti-oxidants liketrans-Resveratrol, Tomato extract (10% lycopene) and Pomegranate extract and their activity was compared with the standard drug Aspirin, which might be beneficial in atherothrombotic conditions. Models used to screen the anti-thrombotic and anti?platelet activities include Aggregation Assay, A-V Shunt Model, Ferric chloride induced thrombosis Model, Bleeding test, Template Bleeding time Model and Pulmonary Thrombosis model.