Phospholipid complex as innovative delivery systems for phytochemicals: A comprehensive review of literature

Various challenges arise when using phytoconstituents, such as the high molecular size, the destruction of drugs due to the lack of lipid solubility in the gastric system. Phospholipid complexation techniques are highly effective in notice these challenges as these techniques enhance the capability to move through permeable membranes and also prevent degradation of natural components by improving solubility. Phospholipid-complex technology, phospholipids complexes not only has the natural ability to release phytoconstituents into circulation, but with this technology they can easily be made into suitable dosage form such as solid unit dosage form. Drug -phospholipid complexes are an admirable choice for internal use because of the many characteristics that help improve it, such as biodegradable, non-toxic, with advantages such as employing them as solubilizers, emulsifiers, and as a matrix forming excipients for poor soluble, permeable drugs. This manuscript mainly focused on the information on different types of techniques used in the preparation of phospholipid complexes. The techniques employed in the formation of phospholipid complexes include selection of different types of phytoconstituents employed in complexes preparation and analytical method employed in its characterization technique also focused. The current review also focuses on basic information as to the best method for increasing the absorption of poorly absorbed plant components and increasing oral bioavailability. The advancement of phospholipid complex by an advanced technique was develop and utilized to based on drug delivery system which not only promotes natural components but also shows the importance of natural components in severe diseases like cancer and mental illnesses. Phospholipid complex drug delivery system is also effective in serious diseases like cancer, mental diseases and gastric problem. This manuscript also provide deep inside of recent patents associated with phospholipid complex in past decade.