FORMULATION AND EVALUATION OF BERBERIN LOADED NANOEMULSION FOR THE TREATMENT OF RHEUMATOID ARTHRITIS

Nanoemulsions are colloidal particulate systems with submicron size particles that function as medication carriers. Their diameter ranges from 10 to 1,000 nanometers. These carriers are solid spheres with an amorphous, lipophilic, negative-charged surface. To improve site-specificity, magnetic nanoparticles can be utilized. As a medication delivery method, they improve the medicine's therapeutic efficacy while reducing side effects and hazardous responses. Infections of the reticuloendothelial system (RES), enzyme replacement therapy in the liver, cancer treatment, and immunization are all examples of major applications. An emulsion is a biphasic framework in which one stage is circulated in the other stage as moment drops with widths changing from 0.1 to 100 lm. A thermodynamically unsound framework must be balanced out by adding an emulsifying specialist (emulgent or emulsifier). The scattered stage is otherwise called the interior stage or the irregular stage, though the scattering medium, outside stage, or persistent stage is the external stage. Middle of the road or interphase is one more name for the emulsifying specialist. A miniemulsion is a fine oil/water or water/oil dispersion stabilized by an interfacial coating of surfactant molecules with droplet sizes ranging from 20 to 600 nanometers. Nanoemulsions are transparent due to their tiny size.