Preparation and Characterization of Solid Lipid Nanoparticles for Artemisinin

Artemisinin is one of the effective antimalarial drugs used in the treatment of malaria. The objective of the research work was to develop solid lipid nanoparticles (SLNs) of artemisinin to enhance its bioavailability. Artemisinin SLNs formulations (ASLN1 to ASLN5) were prepared by the hot homogenization technique and evaluated for its efficacy. The results of characterization studies support the potential and futuristic applications of artemisinin SLNs in the treatment of malaria. SLN of lower particle size (225.4nm); surface charge (-18.7mV) was found to be optimum. The controlled release was achieved up to 24 hr. In conclusion, SLNs can be a promising carrier for the delivery of artemisinin at a controlled rate.