Overview of Acute Myocardial Infarction: Pathophysiology; Diagnosis and Management

Myocardial infarction (MI) was considered a major cause of death and disability worldwide. MI may be the first manifestation of coronary artery disease (CAD) or it may occur, repeatedly, in patients with established disease.In the developed world, roughly 10% of persons who have had a STEMI will die, with the number of MI cases in the US hovering around a million per year.Acute myocardial infarction is often associated with dynamic changes in ECG waveform and serial ECG acquisition can provide critical information, particularly if the ECG at initial presentation is non-diagnostic. After initial evaluation, coronary angiography may be used in patients with evidence of ongoing ischemia (ECG findings or symptoms), hemodynamic instability, recurrent ventricular tachyarrhythmias, and other abnormalities that suggest recurrence of ischemic events.Initial therapy for acute MI is directed toward restoration of perfusion. This may be accomplished through medical or mechanical means, such as percutaneous coronary intervention (PCI), or coronary artery bypass graft (CABG) surgery. The aim of the present study was to review the pathophysiology; diagnosis and managementof acute myocardial infarction