Flow-FISH of CD34+ CD38- for Measurement of Minimal Residual Disease in Adult Acute Myeloid Leukemia Patients

Flow-FISH of CD34+ CD38- for Measurement of Minimal Residual Disease in Adult Acute Myeloid Leukemia Patients

In acute myeloid leukemia patients, the leukemia initiating cells (LICs) are thought to be found in the CD34+CD38- cell compartment. The LICs subpopulation in some cases combats chemotherapy and may cause minimal residual disease (MRD) and relapse.The aim of this study was to detect MRD with Flow- F...

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Veröffentlicht in:NeuroQuantology 2022-01, Vol.20 (6), p.4183
Hauptverfasser: El Sharkawy, Esmat A, Sayed, Doaa M, Ghobrial, Ayman G, Abd Rabou Ayman A, Elnaggar, Mohamed G, El Sayed Mostafa A
Format: Artikel
Sprache:eng
Schlagworte:
Antibodies
Cancer
Chemotherapy
Disease
Hematology
Leukemia
Remission (Medicine)
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Zusammenfassung:In acute myeloid leukemia patients, the leukemia initiating cells (LICs) are thought to be found in the CD34+CD38- cell compartment. The LICs subpopulation in some cases combats chemotherapy and may cause minimal residual disease (MRD) and relapse.The aim of this study was to detect MRD with Flow- FISH technique after one cycle of induction chemotherapy and comparing the results with blast cell percent.
ISSN:1303-5150
DOI:10.14704/nq.2022.20.6.NQ22411