Coloprotective role of vardenafil against the development of ulcerative colitis in rats through inhibition of NLRP3 signaling pathway

Coloprotective role of vardenafil against the development of ulcerative colitis in rats through inhibition of NLRP3 signaling pathway

Aims:Ulcerative colitis (UC) is a chronic relapsing inflammatory bowel disorder that known to increase the risk of colon cancer. Erectile dysfunction(ED) is common in patients with UC. Vardenafil, which is a drug commonly prescribed for treatment of ED, has been shown to have antioxidant effects; ne...

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Veröffentlicht in:NeuroQuantology 2022-01, Vol.20 (7), p.2566
Hauptverfasser: Yehia, Esraa, Kamel, Elsayed M, Salem, Amal E, Abdullah, Doaa M
Format: Artikel
Sprache:eng
Schlagworte:
Acetic acid
Acids
Animals
Colorectal cancer
Edema
Enzymes
Erectile dysfunction
Inflammation
Inflammatory bowel disease
Medicine
Pathogenesis
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Zusammenfassung:Aims:Ulcerative colitis (UC) is a chronic relapsing inflammatory bowel disorder that known to increase the risk of colon cancer. Erectile dysfunction(ED) is common in patients with UC. Vardenafil, which is a drug commonly prescribed for treatment of ED, has been shown to have antioxidant effects; nevertheless, its significance in UC has not been determined. Thus, this current study was designed to investigate the potential prophylactic effects of vardenafil against acetic acid-induced UC and to identify possible underlying mechanisms
ISSN:1303-5150
DOI:10.14704/nq.2022.20.7.NQ33332