Predicting Breast Cancer Risk Using Simple Blood Parameters

Background: The most common cancer in the world is breast cancer. For Iraq, this tumor is the number one cancer in women. In the countries of middle- and low-income economy. the mammography and other expensive and technologically sophisticated diagnostic methods are unattainable because of elevated costs & deficiency in the trained personnel. The cheap, available, and easy complete blood count reflects the response of cellular immunity in a cancer patient. Any alteration in hematological parameters influences the disease progression. Hematological parameters have been correlated with prognosis in several malignancies. The aim of this study the utility of complete blood countin Predicting Breast Cancer Risk. Patient and methods: A case control study done in breast early detection consultation clinic at cancer management specialized center at Salah Al-Deen Governorate. A convenient sample of patient those visited the clinic during the period 1st Jan. 2020- 30th June 2022 was taken, 50 breast cancer patient were compared with 50 patient with benign breast lesion. Breast ultrasound was taken for both groups then biopsy was taken and send for histopathology depending on the results of histopathology the patient was grouped into the study groups. Final complete blood counts of the patients before pre-biopsy were evaluated in preoperative peripheral blood measurements. These Complete Blood Count parameters were compared between benign and malignant patients. Results: The mean age of the patient were significantly higher than the control group. The right sided breast lesion was 24 (48%) among cases in comparison to control group 16(32%), the left sided lesion was higher among cases than control group 23(46%) in comparison to 15(30%), while lesion in both breast found among control group higher than the cases 3(6%), 19 (38%), respectively. Most of the diagnosed at stage III 21(42%) followed by stage II 20(40%). The mean HB was non significantly lower among cancer patients (10.78±1.9)than control group (11±0.93).there is no significant difference between cases and controls regarding platelet count (329.92±58.04), (285.53±62.15). The red cell distribution width was significantly higher among cases (13.82±1.64) than controls (12.27±0.88). The Neutrophil cell count is significantly higher among cases (3.71±1.5) than controls (2.6±0.5). The Neutrophil Lymphocyte ratio is significantly higher among cases (2.07±1.29) than controls (1.09±0.31). Conclusions: Simple Blood Pa