A Novel Synthetic Approaches of Tetra Substituted Pyridine via an Efficient One-Pot Multicomponent Reaction

Recently , one-pot multicomponent reaction as a green , simple friendly environmental and cheap procedure has been developed to achieve wide range of heterocyclic compounds especially when it possess an application in many applied fields. The imidazole is one of the must important five membered heterocyclic compounds, which prepared in this presentation through solid phase one-pot multicomponent reaction a mong piperonal,p-phenylenediamine,binzile and ammonium acetate enhancement by grinding and microwave irradiation at (270 watt) for (8 min) . The prepared imidazole (1) used later as active units building to obtained the N-acetyl derivative (2) via its reaction with acetic anhydride and the later underwent Claisen-Schmidt reaction to afford the chalcons (3-8) in basic media followed by three component reaction with malononitrile and ammonium acetate to achieve the tetra substituted pyridine (9-14).