HEART FAILURE PREDICTION THROUGH PROTEOMICPROFILING AMONG ELDERLY PATIENTS

Objective: The objective of this research article is the identification of new risk factors for heart failure by proteomic profiling of eighty proteins which has been previously found associated with cardiovascular pathology. Materials and Methods:Proximity extension assay (Proteomic profiling) has been performed in two different communities with varying cohorts in the elderly at the baseline without heart failure. The prospective of the research were Prospective Investigation of the Vasculature (PIV) and Longitudinal Study of Adult Men (LSAM) having respective values (80 events, median age = 70.2 years, n = 901) and (90 events, median age = 77.8 years, n = 685). Incident of heart failure was associated with 29 proteins as observed in PIV with adjusted sex and age. Corrections were made after multiple tests. In LSAM there were 18 proteins associated with heart failure. High level of 9 proteins were related to the incident of heart failure among both the cohorts. Established risk factors were also adjusted. Worsen echocardiographic left ventricular systolic function was associated with growth differentiation factor 15 (GDF-15),urokinase-type plasminogen activator surface receptor (U-PAR), matrix metalloproteinase-12 (MMP-12), tumor necrosis factor-related apoptosis-inducing ligand receptor 2 (TRAIL-R2), spondin-1 (SPON1) and follistatin (FS). P value for all was