Reconstituted Extracellular Vesicles from Human Platelets Decrease Viral Myocarditis in Mice (Small 49/2023)

Regenerative Medicine Extracellular vesicles from healthy human platelets globally control inflammation in the hearts of mice with viral myocarditis by regulating the innate immune response with their heterogenous functional contents. This immunomodulation in part comes from anti‐inflammatory microR...

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Veröffentlicht in:	Small (Weinheim an der Bergstrasse, Germany) Germany), 2023-12, Vol.19 (49), p.n/a
Hauptverfasser:	Beetler, Danielle J., Bruno, Katelyn A., Watkins, Molly M., Xu, Vivian, Chekuri, Isha, Giresi, Presley, Di Florio, Damian N., Whelan, Emily R., Edenfield, Brandy H., Walker, Sierra A., Morales‐Lara, Andrea C., Hill, Anneliese R., Jain, Angita, Auda, Matthew E., Macomb, Logan P., Shapiro, Kathryn A., Keegan, Kevin C., Wolfram, Joy, Behfar, Atta, Stalboerger, Paul G., Terzic, Andre, Farres, Houssam, Cooper, Leslie T., Fairweather, DeLisa
Format:	Artikel
Sprache:	eng
Schlagworte:	cardiomyopathy complement Extracellular vesicles Immune system microRNA Nanotechnology Platelets regenerative medicine TLR4 Vesicles
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Zusammenfassung:	Regenerative Medicine Extracellular vesicles from healthy human platelets globally control inflammation in the hearts of mice with viral myocarditis by regulating the innate immune response with their heterogenous functional contents. This immunomodulation in part comes from anti‐inflammatory microRNAs and prevents cardiac dysfunction during peak acute myocarditis. The therapeutic tested in article number 2303317 by DeLisa Fairweather and co‐workers offers a novel and translatable option for inflammatory cardiovascular diseases.
ISSN:	1613-6810 1613-6829
DOI:	10.1002/smll.202370414