Alteration of The Intestinal Microbiome Among Coronary Artery Disease Patients

BackgroundIntestinal microbiome has been linked to several metabolic and chronic disorders, including coronary artery disease (CAD). Our study aimed to analyze the intestinal microbiome of CAD patients and compare it to the healthy controls.MethodsPubMed, Scopus, Embase, and Web of Science were searched using terms; such as “CAD” and “microbiome”. Only observational controlled studies were included. Analysis was conducted by RevMan software version 5.4.ResultsA significant association was found between the CAD group and increased Simpson and Shannon Indices compared with the control group (MD = 0.04, 95% CI = 0.03 to 0.05, p-value >0.00001 and MD = 0.11, 95% CI = 0.01 to 0.22, p-value = 0.03 respectively). Our analysis yielded a significant association between the CAD group and increased Prevotella genus (MD = 13.27, 95% CI = 4.12 to 22.42, p-value =0.004), Catenibacterium genus (MD = 0.09, 95% CI = 0.09 to 0.10, p-value >0.00001), Pseudomonas genus (MD = 0.54, 95% CI = 0.29 to 0.78, p-value >0.00001), and Subdoligranulum (MD = -0.06, 95% CI = -0.06b to -0.06, p-value 0.00001).ConclusionDysbiosis is an acceptable discriminatory marker of CAD. Decreased B.dorei and B.vulgatus among CAD patients suggests a protective role of these bacteria. Future clinical trials are necessary to investigate the potential benefit of supplementation of these bacteria in treating or preventing CAD.