Synthesis, anti-inflammatory and study of histological changes in the mice liver of 1,3-oxazole and 3,3-dihydro pyrazole derivatives

In this study, an effective compound was prepared that was used in the preparation of a final heterocyclic compound in an attempt to use it as an inflammatory inhibitor, compound (2,4-dichloroaniline) was started to be the compound (2) and a procedure cyclization with the compound (1) to obtain the derivative of oxazole (3) containing the carbonyl group (C=O) that was used to prepare the dihydro pyrazole derivative (4). Tested the effectiveness of the new derivatives in inhibiting inflammation induced by cotton pellets by calculating the percentage of inhibition of granulomas, and the results showed that the prepared compounds (3,4) and three concentrations (1000, 500, 250ppm) respectively, actually inhibited inflammation compared to the antibiotics used that showed efficacy low in inhibition of inflammation, as the dry weight of the granuloma, was significantly reduced by using the compounds (3,4) compared to the control group, in addition to the possibility of using its safety because it did not possess any toxicity by calculating the LD50 of the new derivatives on mice, and does not affect on the liver tissue in mice.