Synthesis of Some Benzimidazole-Thiophene Hybrids as Potential Urease and Lipase Inhibitors

In this study, some benzimidazole-thiophene hybrid compounds containing isatin and salicyl moieties were synthesized and investigated for their urease and lipase inhibition properties. Most of the synthesized compounds were found to show effective antiurease activities, when compared with standard Thiourea (0.5027 ± 0.0293 µM). The synthesized isatin containing hybrids ( IVa–IVc ) showed antiurease inhibitory activities ranging from 0.411 ± 0.0337 to 0.431 ± 0.0446 µM, while IC 50 of standard thiourea was 0.5027 ± 0.0293 µM. The general of salicyl containing hybrids showed low antiurease inhibitory activities, while compound ( Ve ) showed 0.338 ± 0.0387 µM activity. The lipase inhibition activities of the synthesized hybrid molecules showed the activities ranging from 0.287 ± 0.0341 to 0.912 ± 0.0832 µM, while the standard Orlistat showed 0.21 ± 0.012 µM activity. In the light of the information obtained from this study, the results showed that the synthesized hybrid compounds could be potential antilipase and antiurease agents.