Synthesis of (Z)-5-((Substituted-2-(substituted phenyl)-quinoline-3-yl)methylene) Thiazolidinone as Antimicrobial and Anticancer Agent

A simplistic synthesis of ( Z )-5-((substituted-2-(substituted phenyl)quinolin-3-yl)methylene)-2-thioxothiazolidin-4-one derivatives has been accomplished by employing acetic acid as the solvent and sodium acetate as the catalyst. We used the Suzuki-Miyaura cross coupling reaction to create carbon-carbon bonds. Our method is practical and has many benefits, such as a quicker reaction time and a higher yield under reflux conditions. For their anticancer and antibacterial activities, all produced compounds were described and tested. Compounds are some of these ( IVa ), ( IVb ), and ( IVc ) manifest significant antimicrobial activity. The compounds ( IVe ), ( IVf ), ( IVg ), and ( IVh ) show prominent antifungal activity. The compounds ( IVi ), ( IVj ), ( IVk ), and ( IVl ) against the breast cancer cell lines MCF-7 and MCF-10A, demonstrates strong anticancer activity. These findings imply that the rhodanine analogues might represent a fresh, potential model for anticancer and antibacterial medicines.