Hypervalent Iodine‐Mediated Alkyne Functionalization: Facile Access to Trifluoromethyl‐ and Pentafluoroethyl‐Substituted Thiazoles

The use of hypervalent iodine with Lewis acid provided alkyne trifluoromethylation and pentafluoroethylation to access trifluoro‐and pentafluoro‐substituted thiazoles. This simple and efficient method is compatible with a broad range of aryl‐ and alkyl‐substituted thiourea starting materials. Additionally, a gram‐scale reaction proves the practicality of this transformation. The use of hypervalent iodine with Lewis acid provided alkyne trifluoromethylation and pentafluoroethylation to access trifluoro‐and pentafluoro‐substituted thiazoles.