Two New Antibacterial Naphthoquinones from a Cigar Tobacco-Derived Endophytic Fusarium solani
In this study, two new ( 1 and 2 ), together with five known ( 3–7 ) naphthoquinones were isolated from the cigar tobacco-derived endophytic Fusarium solani . Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. The new compounds were evaluated fo...
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| Veröffentlicht in: | Chemistry of natural compounds 2023-11, Vol.59 (6), p.1051-1055 |
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| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | In this study, two new (
1
and
2
), together with five known (
3–7
) naphthoquinones were isolated from the cigar tobacco-derived endophytic
Fusarium solani
. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. The new compounds were evaluated for antibacterial activities against
Pseudomonas syringae
(the main pathogenic sources of tobacco angular leaf spot disease). Interestingly, compounds
1
and
2
exhibited inhibitory effects with MIC
50
values of 6.8 and 5.9 μg/mL, respectively. These rates are lower than that of the positive control (agricultural streptomycin, with MIC
50
of 2.2 μg/mL). |
|---|---|
| ISSN: | 0009-3130 1573-8388 |
| DOI: | 10.1007/s10600-023-04194-2 |