Titelbild: Deciphering the Role of the Ser‐Phosphorylation Pattern on the DNA‐Binding Activity of Max Transcription Factor Using Chemical Protein Synthesis (Angew. Chem. 47/2023)

A library of synthetic full‐length Max transcription factor variants with distinct modifications was prepared to investigate the impact of Ser phosphorylation, as reported by Ariel Afek, Muhammad Jbara et al. in their Research Article (e202310913). Comprehensive DNA binding analysis and high‐throughput screening revealed that the phosphorylation pattern plays a crucial role in DNA‐binding activity but does not affect sequence specificity. The insights gained into the regulatory role of Max phosphorylation shed light on how post‐translational modifications influence transcription factor activity.