Synthesis, radiolabeling and in vitro evaluation of azathioprine loaded magnetic solid lipid nanoparticles

In this study, it is aimed to design a smart drug delivery system for the diagnosis and treatment of cancer cells. Magnetic-solid lipid nanoparticles were synthesized as a drug delivery system and azathioprine (AZA) was loaded into this system. This newly created system was radiolabeled using technetium-99 m with a radiolabeling yield of 90.3%. Drug loading into the SLMNP was found as 86%. The biological behavior of 99m Tc and radiolabeled magnetic solid lipid nanoparticles loaded with azathioprine ( 99m Tc-AZA-SLMNP) was investigated in vitro and in vivo. Graphical abstract