A Trojan‐Horse‐Like Biomimetic Nano‐NK to Elicit an Immunostimulatory Tumor Microenvironment for Enhanced GBM Chemo‐Immunotherapy (Small 44/2023)

Biomimetic Nanoparticles In article number 2301439, Rutong Yu, Xiuping Zhou, and co‐workers construct a Trojan‐horse‐like nanoparticle system (R‐NKm@NPs), which traverses across the blood‐brain barrier (BBB) and targets glioblastoma through the natural killer (NK) cell membrane decorated with cRGD. Notably, the R‐NKm@NPs exhibit good antitumor ability by locally releasing temozolomide (TMZ) and IL‐15, eliciting an immunostimulatory tumor microenvironment (TME) and chemo‐immunotherapy response.