A green and one-pot synthesis of 6-amino-1,4-dihydropyrano[2,3-c]-pyrazole-5-carbonitrile derivatives using CoCeO2 nanoparticles as an efficient, reusable and heterogeneous catalyst

In the present study, a novel, facile and environmentally benign protocol for the synthesis of pharmaceutically active 6-amino-1,4-dihydropyrano[2,3- c ]-pyrazole-5-carbonitrile derivatives using CoCeO 2 (nanoparticles) NPs as an efficient, reusable and heterogeneous catalyst in aqueous medium is described. The CoCeO 2 NPs were successfully synthesised using a simple co-precipitation method and confirmed using XRD, FESEM and HRTEM techniques. The high yields of the product, short reaction time, use of non-toxic materials, simple workup and reusability of the catalyst without loss of activity are the superior advantages of the present protocol.