Palladium-catalyzed bicyclization of alkynyl aryl iodide with allenyl malonates

Palladium-catalyzed bicyclization of alkynyl aryl iodide with allenyl malonates

A palladium-catalyzed highly regio- and stereoselective reaction of alkynyl aryl iodide with allenyl malonates was realized to afford a series of bicyclic compounds. The cascade process involves intramolecular carbopalladation of internal alkynes/intermolecular carbopalladation of allenes/cyclizatio...

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Veröffentlicht in:Organic Chemistry Frontiers 2023-10, Vol.10 (21), p.5451-5456
Hauptverfasser: Zhou, Ping-Xin, Liu, Yang, Du, Xueyan, Liu, Ning, Li, Kexin, Wu, Yuji, Feng, Wang, Liu, Xu, Kong, Yingying
Format: Artikel
Sprache:eng
Schlagworte:
Alkynes
Aromatic compounds
Functional groups
Iodides
Organic chemistry
Palladium
Stereoselectivity
Substrates
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Beschreibung
Zusammenfassung:A palladium-catalyzed highly regio- and stereoselective reaction of alkynyl aryl iodide with allenyl malonates was realized to afford a series of bicyclic compounds. The cascade process involves intramolecular carbopalladation of internal alkynes/intermolecular carbopalladation of allenes/cyclization. This new approach has good functional group compatibility and broad substrate scope.
ISSN:2052-4129
2052-4110
2052-4129
2052-4110
DOI:10.1039/D3QO01169K