Alkyl radicals from diacyl peroxides: metal-/base-/additive-free photocatalytic alkylation of N -heteroaromatics

Alkyl radicals from diacyl peroxides: metal-/base-/additive-free photocatalytic alkylation of N -heteroaromatics

Alkyl diacyl peroxides were demonstrated to be efficient alkylating reagents for the visible-light-induced 4CzIPN-catalyzed direct C–H alkylation of N -heteroaromatics. With this metal-/base-/additive-free photocatalytic system, 57 examples of alkylated N -heteroaromatics scaffolds including 1,2,4-t...

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Veröffentlicht in:Green chemistry : an international journal and green chemistry resource : GC 2023-10, Vol.25 (20), p.7971-7977
Hauptverfasser: Cheng, Fukun, Fan, Lulu, Lv, Qiyan, Chen, Xiaolan, Yu, Bing
Format: Artikel
Sprache:eng
Schlagworte:
Alkylation
Green chemistry
Light effects
Peroxides
Quinoxalines
Reagents
Triazine
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Zusammenfassung:Alkyl diacyl peroxides were demonstrated to be efficient alkylating reagents for the visible-light-induced 4CzIPN-catalyzed direct C–H alkylation of N -heteroaromatics. With this metal-/base-/additive-free photocatalytic system, 57 examples of alkylated N -heteroaromatics scaffolds including 1,2,4-triazine-3,5(2 H ,4 H )-diones ( i.e. azauracils), quinoxalin-2(1 H )-ones, 2 H -benzo[ b ][1,4]oxazin-2-ones and quinoxalines were successfully synthesized.
ISSN:1463-9262
1463-9270
DOI:10.1039/D3GC02545D