Effects of BMP-2 on Bone Response using Gelatin Hydrogel in Estrogen-deficient Rats
This study was designed to examine the effects of bone morphogenetic protein-2 (BMP-2) on bone response at palatal site using gelatin hydrogel in ovariectomized (OVX group) and normal female rats (Normal group). The experimental sites in both groups were divided into two sites: implantation with gel...
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| Veröffentlicht in: | Journal of Oral Tissue Engineering 2022, Vol.20(2), pp.41-46 |
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| container_title | Journal of Oral Tissue Engineering |
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| creator | YAMAJI, Kozo YOKOYAMA, Akihito MATSUZAKI, Kumiko SUGAYA, Tsutomu SHIMADA, Yasushi OHARA, Naoko YOSHIYAMA, Masahiro |
| description | This study was designed to examine the effects of bone morphogenetic protein-2 (BMP-2) on bone response at palatal site using gelatin hydrogel in ovariectomized (OVX group) and normal female rats (Normal group). The experimental sites in both groups were divided into two sites: implantation with gelatin hydrogel containing BMP-2 (BMP site) and gelatin hydrogel only (Gel site). Four weeks after implantation, new bone formation was observed at every site and the new bone volume (NBV) of the BMP site was significantly greater than that of the Gel site of both groups (p |
| doi_str_mv | 10.11223/jarde.20.41 |
| format | Article |
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The experimental sites in both groups were divided into two sites: implantation with gelatin hydrogel containing BMP-2 (BMP site) and gelatin hydrogel only (Gel site). Four weeks after implantation, new bone formation was observed at every site and the new bone volume (NBV) of the BMP site was significantly greater than that of the Gel site of both groups (p<0.05). The NBV of every site in Normal group was significantly greater than that of the same experimental site in OVX group (p<0.05).These results suggest that the gelatin hydrogel containing BMP-2 induce new bone formation at palatal site even in estrogen-deficient rats, whereas the new bone volume is less than in normal rats.</description><identifier>ISSN: 1348-9623</identifier><identifier>EISSN: 1880-0823</identifier><identifier>DOI: 10.11223/jarde.20.41</identifier><language>eng ; jpn</language><publisher>Okayama: Japanese Association of Regenerative Dentistry</publisher><subject>BMP-2 ; bone formation ; Bone growth ; Bone morphogenetic protein 2 ; Bone morphogenetic proteins ; Estrogens ; Gelatin ; Hydrogels ; Implantation ; Osteogenesis ; osteoporosis ; Ovariectomy</subject><ispartof>Journal of Oral Tissue Engineering, 2022, Vol.20(2), pp.41-46</ispartof><rights>2022 by Japanese Association of Regenerative Dentistry</rights><rights>2023. This work is published under https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,4024,27923,27924,27925</link.rule.ids></links><search><creatorcontrib>YAMAJI, Kozo</creatorcontrib><creatorcontrib>YOKOYAMA, Akihito</creatorcontrib><creatorcontrib>MATSUZAKI, Kumiko</creatorcontrib><creatorcontrib>SUGAYA, Tsutomu</creatorcontrib><creatorcontrib>SHIMADA, Yasushi</creatorcontrib><creatorcontrib>OHARA, Naoko</creatorcontrib><creatorcontrib>YOSHIYAMA, Masahiro</creatorcontrib><creatorcontrib>Okayama University Graduate School of Medicine</creatorcontrib><creatorcontrib>Department of Periodontology and Endodontology</creatorcontrib><creatorcontrib>Okayama</creatorcontrib><creatorcontrib>Hokkaido University</creatorcontrib><creatorcontrib>Graduate School of Medical and Dental Sciences</creatorcontrib><creatorcontrib>Department of Operative Dentistry</creatorcontrib><creatorcontrib>Faculty of Dental Medicine</creatorcontrib><creatorcontrib>Tokyo Medicinal and Dental University</creatorcontrib><creatorcontrib>Dentistry and Pharmaceutical Science</creatorcontrib><creatorcontrib>Department of Cariology and Operative Dentistry</creatorcontrib><title>Effects of BMP-2 on Bone Response using Gelatin Hydrogel in Estrogen-deficient Rats</title><title>Journal of Oral Tissue Engineering</title><addtitle>J. Oral Tissue Engin.</addtitle><description>This study was designed to examine the effects of bone morphogenetic protein-2 (BMP-2) on bone response at palatal site using gelatin hydrogel in ovariectomized (OVX group) and normal female rats (Normal group). The experimental sites in both groups were divided into two sites: implantation with gelatin hydrogel containing BMP-2 (BMP site) and gelatin hydrogel only (Gel site). Four weeks after implantation, new bone formation was observed at every site and the new bone volume (NBV) of the BMP site was significantly greater than that of the Gel site of both groups (p<0.05). The NBV of every site in Normal group was significantly greater than that of the same experimental site in OVX group (p<0.05).These results suggest that the gelatin hydrogel containing BMP-2 induce new bone formation at palatal site even in estrogen-deficient rats, whereas the new bone volume is less than in normal rats.</description><subject>BMP-2</subject><subject>bone formation</subject><subject>Bone growth</subject><subject>Bone morphogenetic protein 2</subject><subject>Bone morphogenetic proteins</subject><subject>Estrogens</subject><subject>Gelatin</subject><subject>Hydrogels</subject><subject>Implantation</subject><subject>Osteogenesis</subject><subject>osteoporosis</subject><subject>Ovariectomy</subject><issn>1348-9623</issn><issn>1880-0823</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNpFkEtPAyEUhSdGE2t15w8gcT0VuMyDpW36MKnRVF1PKI_KZAp1oIv-e2mrMYF7Dsk5H4Qsuyd4RAil8NiKXukRxSNGLrIBqWuc45rCZfLA6pyXFK6zmxBajIuSk2qQvU-N0TIG5A0av7zlFHmHxt5ptNJh513QaB-s26C57kS0Di0Oqvcb3aHkpyEevcuVNlZa7SJaiRhusysjuqDvfnWYfc6mH5NFvnydP0-elnkLQFgqCWBcABYC1kRSTolaF0oJydPrjJFMmrowFCogUJUEioIqVVS65GXBeQnD7OHM3fX-e69DbFq_7126sqF1VRHMOLCUmp9TW62sFJ13nXX6P6os-D7a1MGUNhjTtJKQtNlplIxASWqeSLMzqQ1RbHSz6-1W9IdGpLrsEvL4-wnT0OM4nZImyF9Afom-0Q5-ADPhgEE</recordid><startdate>2022</startdate><enddate>2022</enddate><creator>YAMAJI, Kozo</creator><creator>YOKOYAMA, Akihito</creator><creator>MATSUZAKI, Kumiko</creator><creator>SUGAYA, Tsutomu</creator><creator>SHIMADA, Yasushi</creator><creator>OHARA, Naoko</creator><creator>YOSHIYAMA, Masahiro</creator><general>Japanese Association of Regenerative Dentistry</general><general>Japan Science and Technology Agency</general><scope>7QO</scope><scope>7QP</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope></search><sort><creationdate>2022</creationdate><title>Effects of BMP-2 on Bone Response using Gelatin Hydrogel in Estrogen-deficient Rats</title><author>YAMAJI, Kozo ; YOKOYAMA, Akihito ; MATSUZAKI, Kumiko ; SUGAYA, Tsutomu ; SHIMADA, Yasushi ; OHARA, Naoko ; YOSHIYAMA, Masahiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j3314-dea349a30aa3b1c2921db5ddac9056ffc4cf85f2373137613552dd57e69659963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng ; jpn</language><creationdate>2022</creationdate><topic>BMP-2</topic><topic>bone formation</topic><topic>Bone growth</topic><topic>Bone morphogenetic protein 2</topic><topic>Bone morphogenetic proteins</topic><topic>Estrogens</topic><topic>Gelatin</topic><topic>Hydrogels</topic><topic>Implantation</topic><topic>Osteogenesis</topic><topic>osteoporosis</topic><topic>Ovariectomy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>YAMAJI, Kozo</creatorcontrib><creatorcontrib>YOKOYAMA, Akihito</creatorcontrib><creatorcontrib>MATSUZAKI, Kumiko</creatorcontrib><creatorcontrib>SUGAYA, Tsutomu</creatorcontrib><creatorcontrib>SHIMADA, Yasushi</creatorcontrib><creatorcontrib>OHARA, Naoko</creatorcontrib><creatorcontrib>YOSHIYAMA, Masahiro</creatorcontrib><creatorcontrib>Okayama University Graduate School of Medicine</creatorcontrib><creatorcontrib>Department of Periodontology and Endodontology</creatorcontrib><creatorcontrib>Okayama</creatorcontrib><creatorcontrib>Hokkaido University</creatorcontrib><creatorcontrib>Graduate School of Medical and Dental Sciences</creatorcontrib><creatorcontrib>Department of Operative Dentistry</creatorcontrib><creatorcontrib>Faculty of Dental Medicine</creatorcontrib><creatorcontrib>Tokyo Medicinal and Dental University</creatorcontrib><creatorcontrib>Dentistry and Pharmaceutical Science</creatorcontrib><creatorcontrib>Department of Cariology and Operative Dentistry</creatorcontrib><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of Oral Tissue Engineering</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>YAMAJI, Kozo</au><au>YOKOYAMA, Akihito</au><au>MATSUZAKI, Kumiko</au><au>SUGAYA, Tsutomu</au><au>SHIMADA, Yasushi</au><au>OHARA, Naoko</au><au>YOSHIYAMA, Masahiro</au><aucorp>Okayama University Graduate School of Medicine</aucorp><aucorp>Department of Periodontology and Endodontology</aucorp><aucorp>Okayama</aucorp><aucorp>Hokkaido University</aucorp><aucorp>Graduate School of Medical and Dental Sciences</aucorp><aucorp>Department of Operative Dentistry</aucorp><aucorp>Faculty of Dental Medicine</aucorp><aucorp>Tokyo Medicinal and Dental University</aucorp><aucorp>Dentistry and Pharmaceutical Science</aucorp><aucorp>Department of Cariology and Operative Dentistry</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of BMP-2 on Bone Response using Gelatin Hydrogel in Estrogen-deficient Rats</atitle><jtitle>Journal of Oral Tissue Engineering</jtitle><addtitle>J. Oral Tissue Engin.</addtitle><date>2022</date><risdate>2022</risdate><volume>20</volume><issue>2</issue><spage>41</spage><epage>46</epage><pages>41-46</pages><issn>1348-9623</issn><eissn>1880-0823</eissn><abstract>This study was designed to examine the effects of bone morphogenetic protein-2 (BMP-2) on bone response at palatal site using gelatin hydrogel in ovariectomized (OVX group) and normal female rats (Normal group). The experimental sites in both groups were divided into two sites: implantation with gelatin hydrogel containing BMP-2 (BMP site) and gelatin hydrogel only (Gel site). Four weeks after implantation, new bone formation was observed at every site and the new bone volume (NBV) of the BMP site was significantly greater than that of the Gel site of both groups (p<0.05). The NBV of every site in Normal group was significantly greater than that of the same experimental site in OVX group (p<0.05).These results suggest that the gelatin hydrogel containing BMP-2 induce new bone formation at palatal site even in estrogen-deficient rats, whereas the new bone volume is less than in normal rats.</abstract><cop>Okayama</cop><pub>Japanese Association of Regenerative Dentistry</pub><doi>10.11223/jarde.20.41</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of Oral Tissue Engineering, 2022, Vol.20(2), pp.41-46 |
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| source | J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; EZB-FREE-00999 freely available EZB journals |
| subjects | BMP-2 bone formation Bone growth Bone morphogenetic protein 2 Bone morphogenetic proteins Estrogens Gelatin Hydrogels Implantation Osteogenesis osteoporosis Ovariectomy |
| title | Effects of BMP-2 on Bone Response using Gelatin Hydrogel in Estrogen-deficient Rats |
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