Effects of BMP-2 on Bone Response using Gelatin Hydrogel in Estrogen-deficient Rats

Effects of BMP-2 on Bone Response using Gelatin Hydrogel in Estrogen-deficient Rats

This study was designed to examine the effects of bone morphogenetic protein-2 (BMP-2) on bone response at palatal site using gelatin hydrogel in ovariectomized (OVX group) and normal female rats (Normal group). The experimental sites in both groups were divided into two sites: implantation with gel...

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Veröffentlicht in:Journal of Oral Tissue Engineering 2022, Vol.20(2), pp.41-46
Hauptverfasser: YAMAJI, Kozo, YOKOYAMA, Akihito, MATSUZAKI, Kumiko, SUGAYA, Tsutomu, SHIMADA, Yasushi, OHARA, Naoko, YOSHIYAMA, Masahiro
Format: Artikel
Sprache:eng ; jpn
Schlagworte:
BMP-2
bone formation
Bone growth
Bone morphogenetic protein 2
Bone morphogenetic proteins
Estrogens
Gelatin
Hydrogels
Implantation
Osteogenesis
osteoporosis
Ovariectomy
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Zusammenfassung:This study was designed to examine the effects of bone morphogenetic protein-2 (BMP-2) on bone response at palatal site using gelatin hydrogel in ovariectomized (OVX group) and normal female rats (Normal group). The experimental sites in both groups were divided into two sites: implantation with gelatin hydrogel containing BMP-2 (BMP site) and gelatin hydrogel only (Gel site). Four weeks after implantation, new bone formation was observed at every site and the new bone volume (NBV) of the BMP site was significantly greater than that of the Gel site of both groups (p
ISSN:1348-9623
1880-0823
DOI:10.11223/jarde.20.41