A method for the synthesis of 17-pyrimidinylandrostane
A convenient synthesis method for new 17-pyrimidinylandrostanes based on 3β-hydroxy-17-[3-dimethylamino)acryloyl]-16α,17α- epoxyandrost-5-ene is proposed. The reaction of the epoxyandrostene with guanidine and acetamidine yielded 3β-hydroxy-17-(pyrimidin- 4-yl)-16α,17α-epoxyandrost-5-enes, and its r...
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| Veröffentlicht in: | Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2023-08, Vol.59 (8), p.614-617 |
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| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
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| Online-Zugang: | Volltext |
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| Zusammenfassung: | A convenient synthesis method for new 17-pyrimidinylandrostanes based on 3β-hydroxy-17-[3-dimethylamino)acryloyl]-16α,17α- epoxyandrost-5-ene is proposed. The reaction of the epoxyandrostene with guanidine and acetamidine yielded 3β-hydroxy-17-(pyrimidin- 4-yl)-16α,17α-epoxyandrost-5-enes, and its reaction with 3-aminopyrazole or 3-amino-1,2,4-triazole resulted in the formation of the respective 3β-hydroxy-17-(pyrazolo[1,5-
a
]pyrimidin-7-yl)-16α,17α-epoxyandrost-5-ene and 3β-hydroxy-17-(1,2,4-triazolo[1,5-
a
]- pyrimidin-5-yl)-16α,17α-epoxyandrost-5-ene. |
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| ISSN: | 0009-3122 1573-8353 |
| DOI: | 10.1007/s10593-023-03241-8 |