Single-Step Regioselective Oxidative Iodination of Tetrahydrocarbazoles using Periodic Acid in Methanol

Methanol was used as a solvent to perform a one-pot direct oxidation of tetrahydrocarbazoles with periodic acid, followed by regioselective iodination. The oxidative iodination products, substituted 3-iodo-1,2,3,4-tetrahydro-9 H -carbazol-1-ones, were obtained in 60–82% yields. Initial tetrahydrocarbazole derivatives were prepared from cyclohexanone and substituted phenyl hydrazines.