Importance of Prostate-Specific Membrane Antigen in Paget's Disease of the Breast

Keywords: Paget's Disease of the Breast, Prostate Specific Membrane Antigen, Human Epidermal Growth Factor-2 Introduction Prostate specific membrane antigen (PSMA) is a type-2 transmembrane glycoprotein consisting of 750 amino acids, known as glutamate carboxypeptidase 2 or N-acetyl-L-aspartyl-L-glutamate peptidase, with folate hydrolase activity expressed by the prostatic epithelium. The second theory for the development of Paget's disease is that Paget cells arise from malignant keratinocyte cells in situ. [...]Paget's disease is considered as an in-situ cancer that does not invade the deep layer (5). Many studies show that Paget's disease of the breast frequently expresses HER-2 (6,7).HER-2 is an epidermal growth factor receptor with tyrosine kinase activity. [...]the information showing the relationship between PSMA and breast malignancies is limited, there is no literature on PSMA and Paget's disease of the breast; Despite the small number of patients in our study, the high grade and distant metastasis with ki-67 in patients with PSMA staining supports the view that PSMA is considered as a bad prognostic factor and included in routine immunohistochemically studies in Paget's disease.