P05 Myocardial inflammation after myocardial infarction: a prospective 68Ga-DOTATATE PET/MRI and immunophenotyping study

IntroductionInflammation and its resolution modulate ischaemic injury after myocardial infarction (MI). We evaluated somatostatin receptor 2 (SST2) PET/MRI using 68Ga-DOTATATE for assessing post-infarct inflammation.MethodsSST2 PET/MRI was performed at 2 weeks and 3 months after MI in a prospective...

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Veröffentlicht in:	Heart (British Cardiac Society) 2023-10, Vol.109 (Suppl 4), p.A4-A4
Hauptverfasser:	Ćorović, A, Huang, Y, Harrison, J, Gopalan, D, Weir-McCall, J, Gallo, Arianna, Wall, C, Peverelli, M, Calvert, P A, Hoole, S P, Manavaki, R, Fryer, T, Aloj, L, Dweck, M R, Newby, DE, Fayad, Z A, Graves, MJ, Bennett, M R, Mallat, Z, Nus, M, Rudd, JHF, Tarkin, J M
Format:	Artikel
Sprache:	eng
Schlagworte:	Heart attacks Inflammation
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Zusammenfassung:	IntroductionInflammation and its resolution modulate ischaemic injury after myocardial infarction (MI). We evaluated somatostatin receptor 2 (SST2) PET/MRI using 68Ga-DOTATATE for assessing post-infarct inflammation.MethodsSST2 PET/MRI was performed at 2 weeks and 3 months after MI in a prospective longitudinal cohort study. Blood samples were taken for cardiac biomarkers, cell immunophenotyping and proteomic inflammatory markers. Cardiac function and viability were re-assessed at 1 year by MRI.ResultsIn 38 participants (mean age 60 [SD 9] years; 84% male), 68Ga-DOTATATE maximum standardised uptake values (SUVmax) clearly differentiated infarcted myocardium defined by late gadolinium enhancement MRI from remote regions (infarct 2.4 vs. remote 1.4, p
ISSN:	1355-6037 1468-201X
DOI:	10.1136/heartjnl-2023-BSCI.9