Poly-terephthalic acid modified pencil graphite electrode for the electrochemical determination of vitamin B6

Reporting for the first time, a poly-terephthalic acid modified pencil graphite electrode (PGE) for the quantitative detection of pyridoxine or vitamin B6 (VB6) from pharmaceutical samples. The developed sensor was characterized using scanning electron microscopy, energy dispersive X-ray spectroscopy, infrared spectroscopy, and electrochemical impedance spectroscopy. Cyclic and differential pulse voltammetric techniques were used for the investigation of the electro-oxidation of VB6 on the electrode. The characteristic oxidation peak of VB6 was found to be located at a potential of 0.58 V in the supporting electrolyte solution, phosphate buffer solution with pH 7. This novel electrochemical sensor has a linear range of 0.1–3500 μM with an LOD of 0.0102 μM. As a result, the fabricated electrode can be utilized for pharmaceutical analysis.