Anti-inflammatory effects of δ-tocopherol on adipose tissues in rats induced inflammation by LPS administration

Background and objectives: It is known that obesity induces a chronic inflammatory reaction, which causes lifestyle-related diseases such as diabetes, dyslipidemia, and heart disease. Therefore, it is suggested that the inhibition of inflammation leads to suppressing the onset of the lifestyle-relat...

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Veröffentlicht in:Annals of nutrition and metabolism 2023-08, Vol.79, p.1028
Hauptverfasser: Mimura-Nagase, Mana, Yabe, Yoshimi, Tanaka-Yachi, Rieko, Takahashi-Muto, Chie, Ichi, Ikuyo, Fujiwara, Yoko, Kiyose, Chikako
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Sprache:eng
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Zusammenfassung:Background and objectives: It is known that obesity induces a chronic inflammatory reaction, which causes lifestyle-related diseases such as diabetes, dyslipidemia, and heart disease. Therefore, it is suggested that the inhibition of inflammation leads to suppressing the onset of the lifestyle-related disease. Vitamin E is a fat-soluble vitamin present in vegetable oils and nuts and has eight different naturally occurring forms. Four tocopherols (α-, β-, γ-, and δ-tocopherol) and four tocotrienols (α-, β-, γ-, and δ-tocotrienol). Among them, there are many reports on the function of α-tocopherol, but there are few reports on δ-tocopherol. In this study, we investigated about the anti-inflammatory effect of δ-tocopherol on adipose tissue in rats induced inflammation by lipopolysaccharide (LPS) administration. Methods: We used male SD strain rats (3 weeks of old, n=25). Initially, the rats were fed a control diet (high-fat and high-sucrose diet) for 1week to allow them to adapt to the new environment. To avoid differences, the rats were then divided according to their average weight into four groups: the control (C; n=7), LPS (LPS; n=6), LPS+α-tocopherol (LPS+α; n=6), and LPS+δ-tocopherol (LPS+δ; n=6). After 4 weeks, all rats except C group were intraperitoneally administered 1 mg LPS / kg B.W. and rats of C group were administered PBS instead of LPS. After four hours, rats sacrificed under isoflurane anesthesia. Results: Plasma glucose concentration of C group was significantly higher than that of LPS, LPS+α, and LPS+δ group. The gene expressions of TNF-α, IL-6, MCP-1 and IL-1β in perirenal fat of LPS group were remarkably higher than those of the C group. On the other hand, the gene expression of IL-1β in perirenal fat of LPS+δ group tended to decrease compared to the LPS group. Conclusions: According to the above results, we suggested that δ-tocopherol has a potential power of anti-inflammation on adipose tissue of rats. Currently, we continue to examine about signal transduction of inflammation using adipocytes.
ISSN:0250-6807
1421-9697
DOI:10.1159/000530786