Atomization‐Induced High Intrinsic Activity of a Biocompatible MgAl‐LDH Supported Ru Single‐Atom Nanozyme for Efficient Radicals Scavenging
Developing efficient nanozymes to mimic natural enzymes for scavenging reactive radicals remains a significant challenge owing to the insufficient activity of conventional nanozymes. Herein, we report a novel Ru single‐atom nanozyme (SAE), featuring atomically dispersed Ru atoms on a biocompatible M...
Gespeichert in:
Veröffentlicht in: | Angewandte Chemie 2023-09, Vol.135 (38) |
---|---|
Hauptverfasser: | , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | Developing efficient nanozymes to mimic natural enzymes for scavenging reactive radicals remains a significant challenge owing to the insufficient activity of conventional nanozymes. Herein, we report a novel Ru single‐atom nanozyme (SAE), featuring atomically dispersed Ru atoms on a biocompatible MgAl‐layered double hydroxide (Ru
1
/LDH). The prepared Ru
1
/LDH SAE shows high intrinsic peroxidase (POD)‐like catalytic activity, which outperforms the Ru nanoclusters (NCs) nanozyme by a factor of 20 and surpasses most SAEs. The density functional theory calculations reveal that the high intrinsic POD‐like activity of Ru
1
/LDH can be attributed to a heterolytic path of H
2
O
2
dissociation on the single Ru sites, which requires lower free energy (0.43 eV) compared to the homolytic path dissociation on Ru NC (0.63 eV). In addition, the Ru
1
/LDH SAE shows excellent multiple free radicals scavenging ability, including superoxide anion radical (O
2
⋅
−
), hydroxyl radical (⋅OH), nitric oxide radical (NO⋅) and 2, 2‐diphenyl‐1‐picrylhydrazyl radical (DPPH⋅). Given the advantages of Ru
1
/LDH with high enzymatic activities, biosafety, and ease to scale up, it paves the way for exploring SAEs in the practical biological immunity system. |
---|---|
ISSN: | 0044-8249 1521-3757 |
DOI: | 10.1002/ange.202307133 |