Manifestation of antimicrobial activities: Benzotriazole

The present work is formulated on the antimicrobial activities of certain benzotriazole derivatives against a series of Gram-negative bacteria like Pseudomonas aeruginosa and Escherichia coli, Gram positive bacteria like Bacillus subtilis, Staphylococcus aureusas well as fungal strains like Candida albicans, Candida utilis, Aspergillus niger and Aspergillus flavus. The investigation of antimicrobial screening data revealed that most of the compounds showed moderate to good microbial inhibitions activity. Secondly, only few compounds have been found active against 5 or 6 pathogens. In-silico activity has been carried out with novel benzotriazole derivatives N-(3-(1H-benzo[d][1,2,3]triazol-1-yl)propyl)-2,4-dichloroaniline;1a, N-(3-(1H-benzo[d][1,2,3]triazol-1-yl)propyl)-2,4-dinitroaniline; 1b and N-(3-(1H-benzo[d][1,2,3]triazol-1-yl)propyl)-4-methoxyaniline; 1c. The compounds 1(a-c) has been found successfully docked with protein 4CAW: Aspergillus fumigatus N-myristoyl transferase in complex with myristoyl CoA and a pyrazole sulphonamide ligand through H-bonding with best ligand pose energy -12.3686kcal/mol, -10.6038kcal/mol and - 10.2153kcal/mol with docked run: elapsed time 16 sec., 9 sec. and 16 sec. respectively. This work manifested new insight of antimicrobial activity of benzotriazoles.