Cover Picture: Discovery and Engineering of an Ene‐reductase for Kinetic Resolution and Cascade Reduction of Hajos‐Parrish/Wieland‐Miescher Ketones (Adv. Synth. Catal. 17/2023)

The inside cover picture illustrates that the stepwise reduction of Hajos‐Parrish ketone (HPK) by ene‐reductase (ERED)/ketoreductase (KRED) and KRED/ERED cascade. In this study, the authors discovered an ERED and engineered it as (S)‐stereopreferred enzymes, so that it could be used for kinetic resolution and cascade reduction of HPK and Wieland‐Miescher ketone. Details can be found in the research article by Dongyan Li, He Dong and co‐workers. (D. Li, H. Dong, X. Chen, Y. Li, Y. Xu, J. Wang, J. Fang, C. Huang, W. Zhang, X. Jia, S. You, B. Qin, Adv. Synth. Catal. 2023, 365, 2912–2921; DOI: 10.1002/adsc.202300326)