Protective effects of methylsulfonylmethane (MSM) on barrier function injury of porcine intestinal epithelial cells (IPEC-J2) induced by lipopolysaccharide (LPS)

Methylsulfonylmethane (MSM) is a natural organic sulfur component that has anti-inflammatory and antioxidant properties. In this study, injury of porcine intestinal epithelial cell (IPEC-J2) models were used to investigate the effect of MSM on lipopolysaccharide (LPS)-induced porcine intestinal epit...

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Veröffentlicht in:	Canadian journal of animal science 2023-09, Vol.103 (3), p.262-272
Hauptverfasser:	Jiao, Yang, Li, Hengjiang, Ren, Ting, Kim, In Ho
Format:	Artikel
Sprache:	eng
Schlagworte:	anti-inflammatory Cell culture Cell cycle Cytokines Dextran Dextrans Down-regulation Electrical resistivity Enzyme-linked immunosorbent assay epidermal growth factor receptor (EGFR) Epidermal growth factor receptors Epithelial cells Epithelium Gene expression Growth factors Inflammation Injuries Interleukin 1 Interleukin 6 Interleukins intestinal barrier injury Intestine L-Lactate dehydrogenase Lactate dehydrogenase Lipopolysaccharides Membrane permeability methylsulfonylmethane (MSM) mRNA Pharmacology Protein biosynthesis Protein synthesis Proteins Sulfur tight junction function Zonula occludens-1 protein
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Zusammenfassung:	Methylsulfonylmethane (MSM) is a natural organic sulfur component that has anti-inflammatory and antioxidant properties. In this study, injury of porcine intestinal epithelial cell (IPEC-J2) models were used to investigate the effect of MSM on lipopolysaccharide (LPS)-induced porcine intestinal epithelium barrier damage. The results of the cell cycle showed that the cells in the G2/M phase decreased significantly with the supplementation of 300 mmol/L MSM (P
ISSN:	0008-3984 1918-1825
DOI:	10.1139/cjas-2022-0141