Clinical, Physical, and Nutritional Effects of Weight Loss Program for Obese and Infertile patients

Background and objectives: In recent years, obesity and insulin resistance have been reported to reduce fertility Therefore, it is important for obese females who wish to have children to lose weight toward the healthy weight. We examined the effects of a team-based weight loss program on clinical and nutritional changes in obese females seeking infertility treatment. Methods: Forty-seven obese females with a BMI of 30 kg/m2 or more wishing to be treated for infertility and to participate in the weight loss program were enrolled in this study. We analyzed changes in body compositions during the program and compared blood pressure, laboratory data, intake of nutrients and food before and after the weight loss interventions. We compared these parameters between subjects with and without successful pregnancies within one year after the program. Results: During the program period, body weight, body fat mass, skeletal muscle mass, BMI, and body-fat percentage significantly decreased, while the ratio of skeletal muscle mass vs body fat amount significantly increased. Blood pressure, HOMA-IR, AST, and ALT decreased significantly after the program compared to the baseline. Furthermore, the intake of energy, fat, n-6 polyunsaturated fatty acids, carbohydrates, salt, meats, confectioneries, beverages, fat and oils decreased significantly. In contrast, the intakes of light vegetables, mushrooms, algae, and fish and shellfish increased significantly. There were no differences in body weight loss and BMI between those with and without a successful pregnancy. Conclusions: Our team-based weight loss program improved the nutrients, body weight, body compositions, thereby leading to the improvement of blood pressure, liver function and insulin resistance.