Cardioprotective Role of Swertiamarin, a Plant Glycoside Against Experimentally Induced Myocardial Infarction via Antioxidant and Anti-inflammatory Functions

The study examined the protective effects of swertiamarin on rats with experimentally induced myocardial infarction. Three to six week-old male albino Wistar rats were used in this study and experimental myocardial infarction (MI) was induced using isoproterenol. Our results showed that swertiamarin...

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Veröffentlicht in:	Applied biochemistry and biotechnology 2023-09, Vol.195 (9), p.5394-5408
Hauptverfasser:	Wang, Tao, Wu, Shubin, Ibrahim, Ibrahim Abdel Aziz, Fan, Leilei
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Alanine transaminase Antioxidants Ascorbic acid Aspartate aminotransferase Biochemistry Biotechnology Body weight Calcium Carbonyl compounds Carbonyls Catalase Chemistry Chemistry and Materials Science Creatine Creatine kinase Glutathione Glutathione peroxidase Glutathione reductase Glutathione transferase Glycosides Heart Heart attacks Inflammation Interleukin 6 Kinases L-Lactate dehydrogenase Lactate dehydrogenase Myocardial infarction Original Article Oxidative stress Peroxidase Reductases Sodium Superoxide dismutase Tibia Troponin I Tumor necrosis factor-TNF Tumor necrosis factor-α Vitamin E
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Zusammenfassung:	The study examined the protective effects of swertiamarin on rats with experimentally induced myocardial infarction. Three to six week-old male albino Wistar rats were used in this study and experimental myocardial infarction (MI) was induced using isoproterenol. Our results showed that swertiamarin restored the alteration in heart weight, body weight, and heart weight/tibia length ratio of MI-induced rats to basal levels significantly ( p
ISSN:	0273-2289 1559-0291
DOI:	10.1007/s12010-022-04094-1