Imidazole-Thiazolidine-2,4-dione Conjugated 1,2,3-Triazole Derivatives as Tubulin Aiming Antiproliferative Agents

Imidazole-Thiazolidine-2,4-dione Conjugated 1,2,3-Triazole Derivatives as Tubulin Aiming Antiproliferative Agents

A new series of imidazole-thiazolidine-2,4-dione coupled 1,2,3-triazoles ( VIIa–VIIm ) were synthesized using Knoevengal condensation and Cu-catalyzed azide-alkyne cycloaddition as key approaches. Out of all, ( Z )-3-(2-(4-(4-methoxyphenyl)-1 H -1,2,3-triazol-1-yl)ethyl)-5-((1-methyl-1 H -imidazol-2...

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Veröffentlicht in:Russian journal of bioorganic chemistry 2023-10, Vol.49 (5), p.976-987
Hauptverfasser: Nagaraju, Ashwini, Nukala, Satheesh Kumar, Thirukovela, Narasimha Swamy, Manchal, Ravinder
Format: Artikel
Sprache:eng
Schlagworte:
Alkynes
Benzonitrile
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Cycloaddition
Imidazole
Life Sciences
Methylene
Organic Chemistry
Triazoles
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Zusammenfassung:A new series of imidazole-thiazolidine-2,4-dione coupled 1,2,3-triazoles ( VIIa–VIIm ) were synthesized using Knoevengal condensation and Cu-catalyzed azide-alkyne cycloaddition as key approaches. Out of all, ( Z )-3-(2-(4-(4-methoxyphenyl)-1 H -1,2,3-triazol-1-yl)ethyl)-5-((1-methyl-1 H -imidazol-2-yl)methylene)thiazolidine-2,4-dione ( VIId ) exhibited superior activity against three human cell lines like MCF-7 (breast), A549 (lung) and HeLa (cervix) than the standard drug Nocodazole with IC 50 values
ISSN:1068-1620
1608-330X
DOI:10.1134/S1068162023050047