Synthesis of 16-Nitro- and 16-Amino-14,17-ethanoestrane Derivatives

The hydrogenation of 16-nitro-14,17-etheno steroids has been studied using different catalysts. The chemoselectivity criteria have been established, and new bridged estradiol analogs containing nitro, amino, and hydroxyamino groups on the D ring have been obtained. Complete signal assignment in the...

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Veröffentlicht in:	Russian journal of organic chemistry 2023-06, Vol.59 (6), p.980-992
Hauptverfasser:	Baranovsky, A. V., Ladyka, A. S., Sokolov, S. N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry Chemistry and Materials Science NMR Nuclear magnetic resonance Organic Chemistry Sex hormones
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	The hydrogenation of 16-nitro-14,17-etheno steroids has been studied using different catalysts. The chemoselectivity criteria have been established, and new bridged estradiol analogs containing nitro, amino, and hydroxyamino groups on the D ring have been obtained. Complete signal assignment in the NMR spectra of the synthesized compounds has been performed.
ISSN:	1070-4280 1608-3393
DOI:	10.1134/S1070428023060039